Table 1. EC50 Values (nM) of Simeprevir for NS3 Mutants in the Presence of Different Concentrations of LNA–anti-miR-122 (Also See Supplementary Table S1).
| Mutants | Concentrations of LNA-anti-miR-122 |
|||||||
|---|---|---|---|---|---|---|---|---|
| 0 nM | 0.5 nM | 1 nM | 5 nM | 8 nM | 10 nM | 20 nM | 30 nM | |
| WT | 2.4 | 1.1 | 1.2 | 1.5 | ND | 1.6 | 2.0 | 1.8 |
| Q80R | 39.7 | 24.3 | 23.7 | ND | ND | 13.1 | 12.4 | 11.0 |
| Q80K | 34.2 | 23.0 | 26.3 | 19.2 | 16.7 | 18.8 | 23.8 | 17.9 |
| R155K | 189.1 | 149.7 | 94.4 | 93.8 | 190.4 | 140.3 | 139.1 | 173.1 |
| R155T | 64.9 | 14.2 | 30.3 | 29.9 | 16.9 | ND | ND | ND |
| A156G | 69.9 | 32.1 | 34.6 | 14.1 | 35.3 | 39.5 | 42.4 | 44.1 |
| D168A | 2688.6 | 1389.2 | 1058.6 | 1225.6 | 1463.3 | 973.5 | ND | ND |
| D168H | 2033.9 | 1378.0 | 1094.8 | 966.3 | 810.7 | 1045.6 | ND | ND |
| D168T | 1376.7 | 418.7 | 409.5 | 607.0 | 573.6 | 883.7 | ND | ND |
| D168V | 5566.7 | 3101.7 | 2808.2 | ND | ND | 1630.0 | 3623.1 | 5010.9 |
| D168Y | 923.0 | 884.5 | 884.3 | 429.7 | 248.7 | 880.3 | ND | ND |
| Q80R + I170T | 117.7 | 66.7 | 156.4 | 119.3 | 73.7 | 95.2 | ND | ND |
| Q80R + D168E | 1838.3 | 820.9 | 514.2 | 421.5 | 207.5 | 933.3 | ND | ND |
| D168E + N174K | 808.9 | 382.9 | 342.8 | 318.7 | 299.2 | 310.4 | ND | ND |
ND: not determined.