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. 2016 Aug 3;6:31021. doi: 10.1038/srep31021

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Copyright © 2016, The Author(s)

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(A) The left chromatogram represents the sequences of the affected individuals, the right chromatogram represents the sequence of a normal family member, and the arrow indicates the location of the mutations. (B) Alignment of sequences surrounding the P14L mutation in Homo sapiens, Macaca mulatta, Pan troglodytes, Mus musculus, Rattus norvegicus, Bos taurus, and Sus scrofa. Proline on the 14th position in TMCO3 is highly conserved among different species, including Homo sapiens (NP_060375.4), Macaca mulatta (AFI33644.1), Pan troglodytes (XP_001145898.1), Mus musculus (NP_758486.1), Rattus norvegicus (XP_225016.4), Bos taurus (XP_586612.1), Sus scrofa (NP_001254780.1), Cynoglossus semilaevis (XP_008308536.1), Tursiops truncates (XP_004319523.1), and Parus major (XP_015476001.1).