Table 1. IC₅₀ of DOX (24 h) treated with different drug formulations in HuH-7/ADM and HuH-7 cells.

Drug formulation	HuH-7/ADM		HuH-7
	IC50 (μM)	Decreased folda	IC50 (μM)	Decreased foldb
DOX	172.90 ± 12.06	1	1.70 ± 0.10	1
DOX NP	11.96 ± 1.55	14.46	2.06 ± 0.22	0.82
Combo free	7.00 ± 0.45	24.70	1.36 ± 0.05	1.25
Combo NP	2.20 ± 0.05	78.59	1.24 ± 0.02	1.37
ATO	28.14 ± 0.48		31.24 ± 0.36
ATO NP	31.59 ± 0.24		25.55 ± 0.46

^aIndicates the decreased fold of IC₅₀ value compared with free DOX in HuH-7/ADM cells.

^bIndicates the decreased fold of IC₅₀ value compare with free DOX in HuH-7 cells.