Table 1.

Additional data used for the intra-model analysis of metabolomic data.

Data type	Unit	Use case I: semi-quantitative data	Use case II: quantitative data
Cell medium composition (e.g., RPMI medium)	mM	Yes	No
Concentration of Ions and other compounds (e.g., O2, CO2)	mM	O2 defined based on literature	O2 defined based on literature for one of the cell lines
Cell-weight	Preferable gdryweight	Experimental measurement	Defined based on literature for one of the cell lines
Cell count	Cells per ml	Experimental measurement	Not required
Experimental duration (in hours)		Experimental duration	Not required
Detection limits for all detected metabolites (mass spectrometer)	Instrumental limit of detection in ng/mL or LODs in mM	Experimental measurement	Not required
Doubling time	Hours or growth rate	Experimental measurement	Defined in the experiment if possible
Transcriptomic or proteomic data	List of absent genes	Experimental measurement from the same experiment	Not required