Table 3.
Hazard ratio for the incidence of cardiac mortality associated with renal function in the tertile subgroups of body composition
| Outcomes | Cardiac mortality | Cardiac mortality | Cardiac mortality | ||||||
|---|---|---|---|---|---|---|---|---|---|
| BMI | BF | LMI | |||||||
| Tertile 1 | Tertile 2 | Tertile 3 | Tertile 1 | Tertile 2 | Tertile 3 | Tertile 1 | Tertile 2 | Tertile 3 | |
| No. of patients | n = 1003 | n = 993 | n = 993 | n = 996 | n = 997 | n = 996 | n = 996 | n = 997 | n = 996 |
| Total CAD patients (n = 2989), HR (95 % CI) | |||||||||
| No. of cardiac deaths | 65 | 45 | 40 | 50 | 47 | 53 | 68 | 50 | 32 |
| Unadjusted | 3.21 (1.95–5.30) | 1.96 (1.01–3.79) | 3.19 (1.68–6.06) | 3.06 (1.63–5.77) | 2.12 (1.12–4.01) | 3.40 (1.98–5.83) | 2.69 (1.66–4.34) | 2.30 (1.25–4.21) | 2.81 (1.26–6.27) |
| Adjusteda | 2.26 (1.27–4.02) | 0.85 (0.39–1.84) | 0.90 (0.39–2.07) | 1.66 (0.81–3.40) | 0.72 (0.32–1.58) | 1.90 (1.00–3.62) | 2.46 (1.39–4.37) | 0.89 (0.42–1.87) | 0.77 (0.28–2.12) |
| ACS patients (n = 2163), HR (95 % CI) | |||||||||
| No. of cardiac deaths | 50 | 38 | 35 | 36 | 38 | 49 | 56 | 42 | 25 |
| Unadjusted | 3.39 (1.92–5.97) | 2.01 (1.00–4.05) | 3.87 (1.98–7.56) | 2.69 (1.26–5.73) | 2.55 (1.29–5.05) | 3.53 (2.01–6.18) | 2.74 (1.62–4.65) | 2.37 (1.23–4.57) | 3.62 (1.56–8.41) |
| Adjusteda | 1.85 (0.94–3.66) | 0.69 (0.29–1.61) | 1.00 (0.40–2.50) | 1.23 (0.51–2.97) | 0.56 (0.22–1.40) | 1.80 (0.92–3.52) | 1.99 (1.06–3.72) | 0.63 (0.27–1.48) | 0.99 (0.34–2.93) |
Renal function was estimated by levels of the creatinine clearance and binary classified by ≥60 and < 60 min/ml
BMI body mass index; BF body fat; LMI lean mass index; HR hazard ratio; CI confidence interval; CAD coronary artery disease; ACS acute coronary syndrome; ACE angiotensin-converting enzyme; ARBs angiotensin-receptor blockers
aRisk factors adjustment included age, sex, medical history (pre-hypertension and pre-diabetes mellitus), heart function (Killip level), severity of CAD (left main artery and three vessel diseases), discharge medication (statin, ACE inhibitors or ARBs and beta-receptor blockers)