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. 2016 Aug 2;16:91. doi: 10.1186/s12874-016-0189-0

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© The Author(s) 2016

Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 2 — Pooled dose-response association between aripiprazole and mean change in Positive and Negative Syndrome Scale score (solid line). Aripiprazole dosage was modeled with restricted cubic splines in a random-effects model. Dash lines represent the 95 % confidence intervals for the spline model. The placebo group (dose = 0) served as the referent group. Circles indicate observed mean differences in individual studies; size of bubbles is proportional to precision (inverse of variance) of the mean differences. Right axis represents percentage of the maximum predicted effect