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. 2016 Aug 2;16:91. doi: 10.1186/s12874-016-0189-0

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© The Author(s) 2016

Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 3 — Graphical sensitivity analysis for the pooled dose-response curves between aripiprazole and mean change in Positive and Negative Syndrome Scale score. The placebo group (dose = 0) served as the referent group. Right axis represents percentage of the maximum predicted effect. Left panel: different location of the three knots in a restricted cubic spline model. Right panel: different models, restricted cubic splines (solid line), fractional polynomials (dashed line), quadratic polynomial (dotted line), and E _max model (dot-dashed line). Circles indicate observed mean differences in individual studies; size of bubbles is proportional to precision (inverse of variance) of the mean differences