Table 3.
Circulatory treatment and postoperative outcome in patients treated with inotropes because of heart failure on weaning from CPB
| Placebo n = 13 | Glutamate n = 17 | p-value | |
|---|---|---|---|
| Inotropes (total) | 100 % | 100 % | 1.0 |
| Inotropic duration (hours)a | 85 ± 77 | 34 ± 20 | 0.014 |
| Number of inotropes | 1.8 ± 0.7 | 1.3 ± 0.6 | 0.04 |
| Adrenaline | 85 % | 88 % | 1.0 |
| Adrenalin duration (hours)a | 78 ± 82 | 25 ± 19 | 0.016 |
| Adrenalin duration (hours)b | 92 ± 82 | 28 ± 17 | 0.007 |
| Average max dosage μg/kg/minb | 0.031 ± 0.012 | 0.029 ± 0.030 | 0.73 |
| Milrinone | 54 % | 35 % | 0.46 |
| Milrinone duration (hours)a | 33 ± 52 | 9 ± 14 | 0.09 |
| Milrinone duration (hours)b | 60 ± 60 | 27 ± 8 | 0.20 |
| Average max dosage μg/kg/minb | 0.38 ± 0.15 | 0.36 ± 0.02 | 0.78 |
| Noradrenaline | 85 % | 59 % | 0.23 |
| Average max dosage μg/kg/mina | 0.089 ± 0.096 | 0.034 ± 0.033 | 0.03 |
| Average max dosage μg/kg/minb | 0.106 ± 0.095 | 0.058 ± 0.022 | 0.14 |
| IABP | 31 % | 0 % | 0.03 |
| Postoperative outcome | |||
| Time on ventilator (hours) | 109 ± 192 | 6 ± 3 | 0.033 |
| Time on ventilator >48 h | 46 % | 0.0 % | 0.003 |
| ICU stay (hours) | 150 ± 186 | 45 ± 38 | 0.031 |
| Severe circulatory failure | 61.5 % | 11.8 % | 0.007 |
| Stroke within 24 h | 0.0 % | 0.0 % | 1.0 |
| Cardiac mortality | 15.4 % | 5.9 % | 0.56 |
| 30 day mortality | 15.4 % | 5.9 % | 0.56 |
| Hospital mortality | 15.4 % | 5.9 % | 0.56 |
IABP intra-aortic balloon pump, ICU intensive care unit
aaverage for all patients treated with inotropes
baverage for patients treated with specific drug