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Xenobiotic metabolism. Comparison of HepaRG and C3A cultures in monolayers and BALs for (A) CYP3A4 activity and transcript levels of genes encoding (B-C) enzymes related to xenobiotic metabolism (D-E) basolateral transporter proteins, and (F-G) nuclear hormone receptors. ND= not detectable. a=p≤0.05 compared to same cell line in monolayer, b=p≤0.05 compared to C3A cells in the same culture platform.
