Fig. 4.

Effect of acute metformin treatment (∼16 h before isolation of muscles) on glucose uptake in soleus and EDL muscles from WT mice. Filled and open bars represent results from muscles incubated with or without insulin (10,000 μU/ml) respectively. A: basal and insulin-stimulated glucose uptake in soleus muscles from metformin- or saline-treated WT mice. B: basal and insulin-stimulated glucose uptake in EDL muscles from metformin- or saline-treated WT mice. *Significant difference between basal and insulin-stimulated glucose uptake (main effect, P < 0.01); n = 12. Values are means ± SE.