Fig. 8.

Effect of chronic metformin treatment on GLUT4 and hexokinase (HK)II protein expression in soleus and EDL muscles from WT and AMPK KD mice. Gray bars without and with hatches show results from saline- and metformin-treated mice, respectively. A: GLUT4 protein expression in soleus muscle of metformin- or saline-treated WT and AMPK KD mice. B: HKII protein expression in soleus muscle of metformin- or saline-treated WT and AMPK KD mice. C: GLUT4 protein expression in EDL muscle of metformin- or saline-treated WT and AMPK KD mice. D: HKII protein expression in EDL muscle of metformin- or saline-treated WT and AMPK KD mice. ‡Significant difference between genotypes (main effect, P < 0.05); n = 10. Values are means ± SE.