Fig. 8.
Nitric oxide (NO)-dependent vasorelaxation is independent of age and chronic hypoxia. A: N-nitrosoproline (ProliNO)-induced isometric tension normalized to maximum 10 μM serotonin (5-HT)-precontracted tension (%T10 μM 5-HT) for fetal sheep exposed to normoxia and prenatal chronic hypoxia (FN and FH) and newborn sheep exposed to normoxia and prenatal chronic hypoxia (NBN and NBH). B–E: fetal and newborn sheep exposed to normoxia and prenatal chronic hypoxia in the absence of ODQ (NO), in the presence of 10 μM ODQ, and in the presence of NaOH (control) as a vehicle- and time-matched control. Lines show resultant fits with a Hill equation to dose-response relationships. Values are means ± SE. Data were analyzed by 2-way analysis of variance with a Bonferroni posttest analysis for each dose: *P < 0.05, **P < 0.01, ***P < 0.001 between groups (A) or relative to the presence of ProliNO (B–E).