Fig. 9.
Prenatal chronic hypoxia promotes importance of BKCa channels to bradykinin-mediated arterial relaxation in the fetus but stunts normal relaxation in the newborn. A–D: dose-response curves of pulmonary arterial rings exposed to 10 pM–1 μM bradykinin in an additive manner normalized to %T10 μM PE for fetal sheep exposed to normoxia and prenatal chronic hypoxia and newborn sheep exposed to normoxia and prenatal chronic hypoxia in the presence of DMSO (control) and 1 mM tetraethylammonium (TEA) to inhibit BKCa channels. Lines show resultant fits to the dose-response relationships with a Hill equation. Values are means ± SE. Data were analyzed by 2-way analysis of variance with a Bonferroni posttest analysis for each dose: *P < 0.05, **P < 0.01 vs. control.