Table 2.

Chronic hypoxia, maturation, and maximum response of bradykinin-induced relaxation

	Normoxia		Hypoxia
	Fetus	Newborn	Fetus	Newborn
Control	83 ± 2 (14)	11 ± 4* (6)	47 ± 3‡ (14)	47 ± 2‡ (16)
l-NAME	91 ± 5 (5)	42 ± 4† (4)	79 ± 5† (6)	76 ± 3†‡ (7)
Indo	85 ± 10 (5)	19 ± 5 (4)	76 ± 12† (3)	66 ± 7†‡ (4)
ODQ	91 ± 5 (4)	44 ± 6† (3)	79 ± 8† (3)	73 ± 5†‡ (4)
TEA	78 ± 14 (5)	36 ± 5† (4)	73 ± 5† (3)	40 ± 5 (4)

Values (means ± SE) are shown as percentage of tension normalized to control response obtained in high-K solution for phenylephrine-induced contraction for data presented graphically in Figs. 2, 5–7, and 9; number of animals is shown in parentheses. Statistical significance as shown using a 95% confidence interval based on the log (inhibitor) vs. response curve fit to the data:

^*significant increase in maximum response compared with Fetus,

^†significant depression in maximum response compared with Control,

^‡significant difference in maximum response compared with Normoxia counterpart.