Table 2.
Physiological parameters in CD- or HFD-fed mice exposed to air or CAP for 30 days
| CD |
HFD |
|||
|---|---|---|---|---|
| Parameter | Air | CAP | Air | CAP |
| BW, g | 26.13 ± 0.45 | 28.03 ± 0.82 | 33.95 ± 0.83* | 32.56 ± 1.10* |
| Glucose, mg/dl | 121 ± 10 | 124 ± 8 | 139 ± 3 | 134 ± 3 |
| Lung weight/BW, ×103 | 6.00 ± 0.01 | 5.68 ± 0.27 | 5.01 ± 0.14 | 4.91 ± 0.29 |
| Heart weight/BW, ×103 | 4.77 ± 0.18 | 4.72 ± 0.01 | 4.62 ± 0.11 | 5.04 ± 0.20 |
| Liver weight/BW, ×102 | 4.09 ± 0.25 | 4.09 ± 0.18 | 3.73 ± 0.08 | 3.80 ± 0.19 |
| Spleen weight/BW, ×103 | 3.22 ± 0.38 | 3.47 ± 0.52 | 3.36 ± 0.35 | 3.81 ± 1.03 |
| VEGF, pg/ml | 28.10 ± 1.14 | 29.74 ± 0.66 | 28.46 ± 0.64 | 29.02 ± 1.15 |
Data are means ± SE, n = 3–8. Body weight, organ/body weight ratios, blood glucose, and plasma VEGF levels of CD- or HFD-fed mice exposed for 30 days to air or CAP (see Fig. 2A). CAP, concentrated ambient fine particulate matter; CD, control diet (10% kcal fat); HFD, high fat diet (60% kcal fat); BW, body weight; VEGF, vascular endothelial growth factor.
*
P < 0.05 vs. appropriate diet-matched control.