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. Author manuscript; available in PMC: 2016 Aug 3.
Published in final edited form as: Steroids. 2011 Feb 25;76(9):822–828. doi: 10.1016/j.steroids.2011.02.016

Table 1.

Nongenomic androgen signaling and physiological functions in different tissues.

Tissue Physiology Signaling
Pathway		 Specific
Signaling
Proteins		 Downstream
Signaling
Mechanism
Oocytes Oocyte maturation Gβγ; cAMP; MAPK Mos, PELP-1,
Paxillin, Erk,
CDK1		 All-or-none positive
feedback; CDK1
activation
Sertoli
cells 		Spermatogenesis EGFR; MAPK Src, Erk, CREB p90RSK;
CREB-mediated
transcription
Prostate
Cancer 		Proliferation/survival
migration		 EGFR; MAPK PELP-1, Src,
Paxillin,
Caveolin-1, Erk		 Cytoplasmic-nuclear
cross talk;
transcription
Bones Bone turnover MAPK Src/Shc/Erk PCKβ/p66shc/NF-κB;
apoptosis
Muscles Unknown Ca2+; MAPK Ca2+/K+
channels,
PLC,IP3R		 Transient Ca2+
release