Table 3.

Adjusted ORs for health status by gender and age of initiation

	Hypertension	CVD	MDD	GAD	AUD	SUD
	OR (95% CI)	OR (95% CI)	OR (95% CI)	OR (95% CI)	OR (95% CI)	OR (95% CI)
Model to assess gender differences among late initiators (3-a).
Late initiators
Men	1.00	1.00	1.00	1.00	1.00	1.00
Women	1.24 (1.09-1.41)*	1.20 (1.00-1.45)	2.54 (2.22-2.92)*	2.34 (1.84-2.99)*	0.41 (0.33-0.49)*	0.53 (0.45-0.63)*
Model to assess gender differences among early initiators (3-b).
Early initiators
Men	1.00	1.00	1.00	1.00	1.00	1.00
Women	1.04 (0.89-1.22)	1.11 (0.90-1.36)	2.42 (2.11-2.77)*	2.01 (1.59-2.54)*	0.39 (0.33-0.46)*	0.61 (0.53-0.71)*
Model to assess interaction between gender and age of initiation (3-c).
Late initiators
Men	1.00	1.00	1.00	1.00	1.00	1.00
Women	1.24 (1.09-1.41)	1.19 (1.00-1.43)	2.66 (2.33-3.04)	2.46 (1.93-3.13)	0.43 (0.35-0.52)	0.57 (0.48-0.67)
Early initiators
Men	1.10 (0.96-1.26)	1.30 (1.08-1.56)	1.54 (1.33-1.79)	1.47 (1.12-1.93)	1.87 (1.59-2.21)	2.16 (1.87-2.51)
Women	1.17 (0.74-1.85)	1.49 (0.79-2.79)	4.03 (2.52-6.44)	3.16 (1.36-7.36)	0.78 (0.42-1.42)	1.41 (0.83-2.40)
Early initiatiors × women	0.86 (0.70-1.04)	0.96 (0.74-1.25)	0.98 (0.81-1.18)	0.87 (0.63-1.22)	0.97 (0.75-1.25)	1.15 (0.93-1.43)

Adjusted for age, race/ethnicity, education, employment and marital status, number of children and household income, frequency of cigarette use, cigarettes smoked per day and duration of cigarette smoking.

CVD=Cardiovascular disease, MDD=Major Depressive Disorder, GAD=Generalized Anxiety Disorder, AUD=Alcohol Use Disorder, SUD=Substance Use Disorder

^*p<.001