TABLE 1.
Characteristics of LEGACY Girls and Mothers (n = 869)
| BCFH+, n (%) | BCFH–, n (%) | |
|---|---|---|
| n = 441 | n = 428 | |
| Average age, Mean (SD) | 9.5 (2.3) | 9.4 (2.1) |
| Age distribution | ||
| 6 | 53 (12) | 41 (10) |
| 7 | 58 (13) | 50 (12) |
| 8 | 47 (11) | 66 (15) |
| 9 | 64 (15) | 65 (15) |
| 10 | 59 (13) | 66 (15) |
| 11 | 57 (13) | 60 (14) |
| 12 | 49 (11) | 48 (11) |
| 13 | 54 (12) | 32 (8) |
| Race/ethnicity a | ||
| Non-Hispanic white | 321 (73) | 255 (60) |
| Hispanic | 60 (14) | 66 (15) |
| Black/African American | 23 (5) | 44 (10) |
| Asian | 28 (6) | 45 (11) |
| Native Hawaiian/Pacific Islander/multiple ethnicities | 9 (2) | 18 (4) |
| Mother education | ||
| High school or less | 28 (6) | 20 (5) |
| Vocation/tech school/some college | 89 (20) | 84 (20) |
| Bachelor’s degree | 158 (36) | 170 (40) |
| Graduate degree | 162 (37) | 150 (35) |
| Missing | 4 | 4 |
| Site | ||
| California | 148 (33) | 147 (34) |
| Philadelphia | 86 (20) | 61 (14) |
| New York | 63 (14) | 73 (17) |
| Ontario | 75 (17) | 77 (18) |
| Utah | 69 (16) | 70 (16) |
| Family history b | ||
| Mother with breast cancer | 168 (38) | 0 (0) |
| FDR with any cancer | 182 (41) | 20 (5) |
| Has a BRCA1/2+ mother | 62 (14) | — |
| No FDR/SDR with breast cancer, mean (SD), range | 1.2 (0.63), 0–4 | 0.05 (0.25), 0-3 c |
| Development | ||
| Mother-reported Tanner breast (girls aged 6–13 y) | ||
| Stage 1 | 216 (55) | 237 (61) |
| Stage 2 | 69 (17) | 63 (16) |
| Stage 3 | 77 (19) | 50 (13) |
| Stage 4 | 29 (7) | 28 (7) |
| Stage 5 | 5 (1) | 8 (2) |
| Daughter-reported Tanner breast (girls aged 10–13 y only) | ||
| Stage 1 | 29 (14) | 39 (21) |
| Stage 2 | 71 (34) | 59 (31) |
| Stage 3 | 74 (35) | 48 (25) |
| Stage 4 | 31 (15) | 38 (20) |
| Stage 5 | 6 (3) | 6 (3) |
| Have had menses b | 66 (15) | 62 (15) |
FDR = first-degree relative; SDR = second-degree relative.
a
P = .003.
b
Maternal report.
c
Relatives of true-negative parents.