TABLE 3.
Daughter Psychosocial Adjustment Outcomes (Girls Aged 10–13 Years)
| BCFH+, n = 211 | BCFH–, n = 197 | |
|---|---|---|
| Mean (SD), % At-Risk/Clinical or n (%) | Mean (SD), % At Risk/Clinical or n (%) | |
| Internalizing composite | ||
| All girls (10–13 y) | 31.8 (24.9), 4.4% | 31.9 (25.6), 5.1% |
| 10–11 y | 33.0 (23.1), 2.8% | 34.7 (25.9), 4.8% |
| 12–13 y | 30.6 (26.7), 6.2% | 27.8 (24.7), 5.5% |
| Daughters of BRCA1/2+ mother | 24.8 (23.9), 0.0% | 31.9 (25.6), 5.1% |
| Daughters of mother with BC | 28.3 (23.4), 2.2% | 31.9 (25.6), 5.1% |
| BC-specific distress | ||
| Intrusive BC—distress (range 0–18) | 1.9 a (3.3), NA | 1.1 a (2.2), NA |
| Avoidant BC—distress (range 0–20) | 3.6 b (5.7), NA | 1.9 b (4.2), NA |
| Total BC distress (range 0–38) | 5.4 b (8.1), 12%c | 3.0 b (5.4), 5% c |
| 10–11 y | 5.9 c (8.8), 13% | 3.1 c (6.2), 6% |
| 12–13 y | 5.0 d (7.4), 11% | 3.0 d (4.1), 3% |
| Daughters of BRCA1/2+ mother | 4.8 (9.1), 17% | 3.0 (5.4), 5% |
| Daughters of mother with BC | 6.4 (8.5), 16% d | 3.0 (5.4), 5% d |
| Perceived risk of BC | ||
| Perceived risk higher than peers | 76 (38.4) e | 25 (13.7) e |
| 10–11 y | 34 (32.7) e | 11 (10.5) e |
| 12–13 y | 42 (44.7) e | 14 (17.9) e |
| Daughters of BRCA1/2+ mother | 10 (45.5) f | 25 (13.7) f |
| Daughters of mother with BC | 41 (48.0) e , g | 25 (13.7) e |
| Perceived risk: “I don’t know” | 53 (26.8) h | 76 (41.5) h |
| 10–11 y | 34 (32.7) i | 52 (49.5) i |
| 12–13 y | 19 (20.2) | 24 (30.8) |
| Daughters of BRCA1/2+ mother | 10 (45.5) j | 76 (41.5) |
| Daughters of mother with BC | 18 (21.2) f | 76 (41.5) f |
The models also controlled for race/ethnicity and accounted for within family clustering. Daughters with a BRCA1/2+ mother = 25; daughters with a mother with BC = 90. Percentages reflect the percentage with nonmissing data. Means represent Behavioral Assessment System for Children percentile scores. t scores >60 are classified as at risk for clinically significant problems. Impact of Event Scale total scores ≥17 are classified as at risk for clinically significant problems. BC, breast cancer.
P = .01.
P = .001.
P = .02.
P = .008.
P < .001.
P = .002.
P = .005 for comparison with BCFH+ girls of mothers without BC.
P = .004.
P = .03.
P = .04 for comparison with BCFH+ girls whose mother is BRCA1/2 negative/unknown.