TABLE III.
ASSOCIATION BETWEEN TUMOUR BIOLOGICAL PARAMETERS AND CENP-F EXPRESSION IN COHORTS I AND II
| Variable (n) | CENP-F <10% | CENP-F ≥10% | p value |
|---|---|---|---|
| Cohort I | |||
| VEGF-A1 (89) | 0.0702 | ||
| Low | 5 (14) | 3 (5.6) | |
| Intermediate | 23 (66) | 29 (53.7) | |
| High | 7 (20) | 22 (40.7) | |
| Cyclin E3 (91) | 0.0212 | ||
| Low | 29 (83) | 33 (59) | |
| High | 6 (17) | 23 (41) | |
| Telomerase activity4 (86) | 0.0025 | ||
| Median | 0.81 | 3 | |
| Range | 0–54.7 | 0–153 | |
| Myc amplification6 (71) | 0.0037 | ||
| Low | 27 (96) | 29 (67) | |
| Intermediate/High | 1 (4) | 14 (33) | |
| Ploidy (85) | 0.0257 | ||
| Diploid | 19 (61) | 19 (35) | |
| Aneuploid | 12 (39) | 35 (65) | |
| Survivin-nuclear1 (91) | 0.0017 | ||
| Negative | 7 (20) | 5 (9) | |
| <50% | 22 (63) | 21 (37.5) | |
| >50% | 6 (17) | 30 (53.5) | |
| Her26 (88) | 0.4232 | ||
| Grade 0–2 | 29 (85) | 42 (78) | |
| Grade 3 | 5 (15) | 12 (22) | |
| p53 status1 (89) | 0.0952 | ||
| p53 − | 27 (82) | 36 (64) | |
| p53 + | 6 (18) | 20 (36) | |
| Ki671 (89) | 0.1982 | ||
| ≤10% | 11 (32) | 10 (18) | |
| >10% | 23 (68) | 45 (82) | |
| Cohort II | |||
| VEGFR21 (238) | 0.0017 | ||
| Neg/ Low | 76 (50) | 23 (26) | |
| Intermediate | 55 (37) | 44 (51) | |
| High | 20 (13) | 20 (23) | |
| VEGF-A1 (235) | 0.9597 | ||
| Neg/Low | 54 (37) | 35 (39) | |
| Intermediate | 65 (44.5) | 35 (39) | |
| High | 27 (18.5) | 19 (22) | |
| VEGFR11 (275) | 0.3387 | ||
| Neg/Low | 28 (16) | 15 (15) | |
| Intermediate | 75 (42) | 34 (35) | |
| High | 74 (42) | 49 (50) | |
| Phospho-Ets-21 (240) | 0.0017 | ||
| Negative | 59 (37) | 18 (18) | |
| Low | 43 (27) | 34 (35) | |
| Intermediate | 41 (26) | 24 (25) | |
| High | 15 (10) | 22 (22) | |
| Phospho-Erk 1/21 (231) | 0.1907 | ||
| Negative | 66 (43) | 32 (35.5) | |
| Low | 43 (28) | 17(30) | |
| Intermediate | 29 (19) | 13 (19) | |
| High | 16 (10) | 14 (15.5) | |
| Ki671 (260) | <0.0017 | ||
| ≤10% | 76 (42) | 15 (15) | |
| >10% | 106 (58) | 83 (85) |
Values inside parentheses indicate percentages.
1
Measured by immunohistochemistry.
2
Fisher’s exact test.
3
Measured by Western blotting and densitometry.
4
Measured by the telomeric repeat amplification protocol.
5
Mann-Whitney test.
6
Measured by fluorescence in situ hybridisation.
7
Chi-square test for trend.