Figure 1.

Mechanisms whereby ERBB2 and TOM1L1 cooperate to promote invasiveness in breast cancer. V-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2 (ERBB2) induces phosphorylation of upregulated target of myb1-like 1 protein (TOM1L1) on Ser321, which promotes its association, via its GGA and TOM1 (GAT) homology domain, with Toll-interacting protein (TOLLIP) in late-endosomal RAB7+ compartments and membrane-type 1 matrix metalloprotease (MT1-MMP) trafficking to invadopodia for cell invasion. The VPS27/HRS/STAM homology domain (VHS) and the C-terminal sequence (C-ter) of TOM1L1 are highlighted.