Table 1.

Final parameter estimates

Parameter	Estimate	%RSE
Population parameters
k a (1 h −1 )	0.23	6
t lag (h)	0.45	2
k (1 h −1 )	0.31	12
V/F (l)	1337.89	9
k 12 (1 h −1 )	0.11	7
k 21 (1 h −1 )	0.03	7
P 0 (count ml −1 )	0.11	58
G (unitless)	6.67	4
D (unitless)	18.09	5
IC 50 (ng ml −1 )	2.70	10
γ (unitless)	2.46	7
Random effects (standard deviations)
k a	0.14	38
t lag	0.05	33
k	0.29	26
V	0.20	34
k 12	0.06	157
k 21	0.08	129
P 0	1.18	26
G	0.03	183
D	0.04	105
IC 50	0.25	27
γ	0.08	89
Error terms
Additive error PK	4.38E‐09	3.72E + 06
Multiplicative error PK	0.265	7
Additive error PD	26.1	31
Multiplicative error PD	0.558	7