Table 3.

Results of the self‐controlled case series analysis for the outcomes of first MI and first arrhythmia

	Patients (n)	Patient‐years	Events (n)	Age adjusted IRR (95% CI)
Primary outcome: First MI (median follow‐up 14.0 years)
Single risk window
Baseline	962	12 718	876	1
1 year post‐exposure	961	932.5	84	1.07	(0.85, 1.34)	P = 0.58
Multiple risk window
Baseline	962	11 104	731	1
days 1–30 post‐exposure	961	81.08	9	1.32	(0.6, 2.55)	P = 0.41
days 31–90 post‐exposure	954	159.42	20	1.50	(0.96, 2.35)	P = 0.08
days 91–365 post‐exposure	941	694.45	55	0.97	(0.74, 1.29)	P = 0.84
years 1–2 post‐exposure	886	843.08	85	1.27	(1.01, 1.61)	P = 0.04
years 2–3 post‐exposure	800	768.74	60	1.01	(0.77, 1.33)	P = 0.92
Secondary outcome: first arrhythmia (median follow‐up 15.0 years)
Single risk window
Baseline	552	7727.83	498	1
1 year post‐exposure	552	542.11	50	1.24	(0.92, 1.68)	P = 0.16
Multiple risk window
Baseline	552	6761.63	432	1
days 1–30 post‐exposure	552	46.57	5	1.42	(0.58, 3.44)	P = 0.44
days 31–90 post‐exposure	548	91.83	14	2.04	(1.19, 3.51)	P = 0.01
days 91–365 post‐exposure	543	405.14	31	0.99	(0.68, 1.45)	P = 0.97
years 1–2 post‐exposure	514	500.77	35	0.89	(0.63, 1.27)	P = 0.53
years 2–3 post‐exposure	473	464	31	0.83	(0.57, 1.2)	P = 0.33

All IRRs are age adjusted and derived from conditional Poisson regression. MI myocardial infarction, CI confidence interval, IRR incidence rate ratio