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. Author manuscript; available in PMC: 2016 Aug 3.
Published in final edited form as: J Med Chem. 2015 Jul 21;58(15):5770–5780. doi: 10.1021/acs.jmedchem.5b00356

Figure 3. Heptamidine analogues partially rescue mis-splicing of minigene reporters.

Figure 3

(a) General synthetic schematic for heptamidine derivatives 4 and 6.

(b) RT-PCR data of INSR splicing in cells incubated with increasing concentrations of compounds 4 and 6. Results are depicted as average percentage of exon 11 inclusion ± standard deviation of three independent trials.

(c) Jitter plot representation of INSR splicing in cells treated with compounds 4 and 6. Asterisks indicate a significant difference between the treatment concentration and mis-splicing without compound.