(a) General synthetic schematic for heptamidine derivatives 4 and 6.
(b) RT-PCR data of INSR splicing in cells incubated with increasing concentrations of compounds 4 and 6. Results are depicted as average percentage of exon 11 inclusion ± standard deviation of three independent trials.
(c) Jitter plot representation of INSR splicing in cells treated with compounds 4 and 6. Asterisks indicate a significant difference between the treatment concentration and mis-splicing without compound.