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. Author manuscript; available in PMC: 2016 Aug 3.
Published in final edited form as: J Med Chem. 2015 Jul 21;58(15):5770–5780. doi: 10.1021/acs.jmedchem.5b00356

Figure 4. N-substituted pentamidine derivatives demonstrate increased toxicity in cellulo.

Figure 4

(a) General synthetic schematic for precursor to aminopropyl-substituted compounds.

(b) Jitter plot representation of INSR splicing in cells treated with compound 8. Below, representative RT-PCR gel is demonstrated, with average percentage values (± standard deviation) listed per each condition. Asterisks indicate a significant difference between the treatment concentration and mis-splicing without compound.

(c) General synthetic schematic for phenyl-substituted (9a–9c) and N′N-dimethylaminopropyl-substituted (10a–10c) compounds.

(d & e) Jitter plot representation of INSR splicing in cells treated with compounds 9a–9c (d) and 10a–10c (e). Below, representative RT-PCR gels are demonstrated, with average percentage values (± standard deviation) listed per each condition. Asterisks indicate a significant difference between the treatment concentration and mis-splicing without compound.