(a) General synthetic schematic for precursor to aminopropyl-substituted compounds.
(b) Jitter plot representation of INSR splicing in cells treated with compound 8. Below, representative RT-PCR gel is demonstrated, with average percentage values (± standard deviation) listed per each condition. Asterisks indicate a significant difference between the treatment concentration and mis-splicing without compound.
(c) General synthetic schematic for phenyl-substituted (9a–9c) and N′N-dimethylaminopropyl-substituted (10a–10c) compounds.
(d & e) Jitter plot representation of INSR splicing in cells treated with compounds 9a–9c (d) and 10a–10c (e). Below, representative RT-PCR gels are demonstrated, with average percentage values (± standard deviation) listed per each condition. Asterisks indicate a significant difference between the treatment concentration and mis-splicing without compound.