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. Author manuscript; available in PMC: 2016 Aug 3.
Published in final edited form as: J Med Chem. 2015 Jul 21;58(15):5770–5780. doi: 10.1021/acs.jmedchem.5b00356

Figure 7.

Figure 7

Compound 13 rescues mis-splicing in a DM1 mouse model. a) Compound 13 was able to partially rescue the chloride channel endogenous event by 20 mg/kg for 7 d. b) Compound 13 was also able to partially rescue the sarcoplasmic calcium ATPase 1 endogenous event by 20 mg/kg for 7 d. No toxicity was observed over the concentration range tested. Each symbol represents the splicing outcome for quadriceps muscle of a single mouse. Gray area denotes range of splicing between wild type and DM mis-splicing patterns. Asterisks denote events that were significantly different from HSALR mice.