Table 1. Efficacy (EC50) and cytotoxicity (IC50) values for diamidine derivatives of pentamidine and heptamidine.
EC50 | IC50 | EC50:IC50 | |
---|---|---|---|
Pentamidine | 31 ± 2 | 64 ± 12 | 0.48 |
Heptamidine | 9 ± 1 | 15 ± 0.46 | 0.60 |
4 | 14 ± 5.2 | 30 ± 4.9 | 0.47 |
6 | 75 ± 11 | 91 ± 8.4 | 0.82 |
8 | 70 ± 12 | 355 ± 45.1 | 0.20 |
9a | 40* ± 9.3 | 13 ± 2.9 | 3.08 |
9b | 10.5* ± 5.4 | 11 ± 1.6 | 0.95 |
9c | 10.4* ± 2.9 | 5 ± 0.26 | 2.08 |
10a | 366* ± 14.9 | 551 ± 35.4 | 0.66 |
10b | 393* ± 94.2 | 414 ± 31.2 | 0.95 |
10c | 256* 68.2 | 217 ± 16.2 | 1.18 |
11 | 125* 54.4 | 134 ± 55.8 | 0.93 |
12 | 31 ± 4 | 210 ± 19.3 | 0.15 |
13 | 30 ±4 | N/A | N/A |