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. Author manuscript; available in PMC: 2017 Apr 11.
Published in final edited form as: Angew Chem Int Ed Engl. 2016 Mar 17;55(16):4943–4946. doi: 10.1002/anie.201511350

Figure 1.

Figure 1

A) Crystal structure of firefly luciferase bound to a luciferyl-adenylate analog[10] (PDB 4G36, rendered in PyMOL). Mutations to R218, L286, and S347 in the luciferin binding pocket have allowed tuning of substrate specificity.[7,8] L342 does not contact the core luciferin structure and is distal from the structural differences between D-luciferin, CycLuc1 and CycLuc2 (B).