Table 2.

IC₅₀ values of the amide-bridged AIP analogues against AgrCs I–IV determined using S. aureus fluorescence reporter strains.^[a]

Peptide name	Inhibition (IC50nM)[b]
	AgrC-I	AgrC-II	AgrC-III	AgrC-IV
AIP-III Amide	>1000	>1000	75.2	299
AIP-III D4A Amide	1.20	2.19	0.0551	0.192
tAIP-III D2A Amide	1.50	13.9	0.216	0.189
AIP-III[c]	5.05	5.63	-[d]	8.53
AIP-III D4A[c]	0.485	0.429	0.0506	0.0349
tAIP-III D2A[c]	0.257	0.900	0.329	0.0957

^aSee SI for details of reporter strains and methods, and antagonism dose response curves.

^bSee SI for 95% confidence ranges.

^cControl peptides, data from ref.[6a].

^dReceptor agonist.