Figure 4.

Transcriptional coherence of divergent gene pairs with and without conserved binding sites. A, The distribution of absolute PCCs for all divergent gene pairs is split into four categories. These categories are divergent gene pair, divergent gene pair with orientation conservation, divergent gene pair with conserved binding site, and divergent gene pair with conserved binding site and orientation conservation. Asterisks indicate that the P value of the Wilcoxon rank-sum test was less than 0.05 (*) and 0.01 (**), respectively. B, Two examples of conserved mini-regulons. The conserved binding site is indicated in the center, together with the PCCs between the TF and the divergent genes. Below the divergent genes, the orthologous genes with conserved divergent configurations and the presence of a conserved binding site in other species are shown.