Table 2.
Patient and tumor characteristics (N = 567)
| Characteristic | ACCI 0–1 (Low) n = 199 (35%) |
ACCI 2–3 (Intermediate) n = 271 (48%) |
ACCI ≥4 (High) n = 97 (17%) |
p |
|---|---|---|---|---|
|
| ||||
| Median age (range) | 51 years (23 – 59) | 65 years (43 – 79) | 74 years (60 – 96) | <0.001 |
|
| ||||
| Median body mass index (range) | 25.2 kg/m2 (16.3 – 43.7) | 25.7 kg/m2 (17.6 – 54.6) | 25 kg/m2 (18.3 – 50.1) | 0.49 |
|
| ||||
| FIGO Stage | ||||
| IIIB | 10 (5%) | 8 (3%) | 5 (5%) | 0.01 |
| IIIC | 148 (74%) | 226 (83%) | 86 (89%) | |
| IV | 41 (21%) | 37 (14%) | 6 (6%) | |
|
| ||||
| Primary disease site | ||||
| Ovary | 167 (84%) | 204 (75%) | 74 (76%) | 0.19 |
| Fallopian tube | 16 (8%) | 28 (10%) | 9 (9%) | |
| Peritoneum | 16 (8%) | 39 (15%) | 14 (15%) | |
|
| ||||
| Histology | ||||
| Serous | 181 (91%) | 249 (92%) | 81 (84%) | 0.1 |
| Endometrioid | 1 (1%) | 2 (1%) | 2 (2%) | |
| Clear cell | 2 (1%) | 0 (0%) | 0 (0%) | |
| Mixed/Other | 15 (8%) | 20 (7%) | 14 (14%) | |
|
| ||||
| Tumor grade | ||||
| 1 | 8 (4%) | 7 (3%) | 3 (3%) | 0.6 |
| 2 | 16 (8%) | 14 (5%) | 5 (5%) | |
| 3 | 175 (88%) | 250 (92%) | 89 (92%) | |
|
| ||||
| Median preoperative albumin (range) * | 4.1 g/dL (2.5 – 4.8) | 4.1 g/dL (2.1 – 5) | 4.1 g/dL (2.4 – 4.8) | 0.97 |
|
| ||||
| Median preoperative platelet count (range) | 367 K/μl (204 – 1067) | 366 K/μl (175 – 920) | 314 K/μl (113 – 1067) | <0.001 |
|
| ||||
| Median preoperative CA-125 (range) † | 681 U/mL (3 – 28,503) | 496 U/mL (3 – 38,100) | 444 U/mL (9 – 24,500) | 0.05 |
|
| ||||
| Ascites | ||||
| None | 50 (25%) | 74 (27%) | 38 (39%) | 0.09 |
| 1 – 1000 ml | 57 (29%) | 71 (26%) | 24 (25%) | |
| 1001 – 5000 ml | 73 (37%) | 92 (34%) | 31 (32%) | |
| >5000 ml | 19 (9%) | 34 (13%) | 4 (4%) | |
|
| ||||
| Residual disease | ||||
| None | 87 (44%) | 86 (32%) | 31 (32%) | 0.02 |
| ≤1 cm | 77 (39%) | 107 (39%) | 37 (38%) | |
| >1 cm | 35 (17%) | 78 (29%) | 29 (30%) | |
|
| ||||
| Median time to adjuvant chemotherapy (range) ‡ | 32 days (4 – 90) | 31 days (2 – 93) | 35 days (4 – 72) | 0.27 |
|
| ||||
| Intraperitoneal chemotherapy administration (optimally debulked patients 2005 – 2010) | 64/101 (63%) | 60/124 (48%) | 20/36 (56%) | 0.08 |
ACCI: Age-adjusted charlson comorbidity index; FIGO, International Federation of Gynecology and Obstetrics
Data missing for:
*
8,
†
24, and
‡
20 patients.