Fig 6. Examples of pathology and impacts on analyses.

Row A: The child for whom a surface could not be generated. Tissue segmentation failed as the allowed magnitude of warping was insufficient to match any atlas, leading to cerebrospinal fluid being classed as grey and white matter. Voxelwise analyses were successful. Rows B and C: Two participants for whom surface analyses were successful, but voxelwise analyses failed to detect significant fMRI activation. Row D: A child with severe pathology for whom both voxelwise and surface analyses detected fMRI activation. Both methods found no corticomotor or thalamocortical tracks in the hemisphere with pathology; no genuine connections of this type were probably present.