Microcirculatory changes that occur during acute pancreatitis (CCK, cholecystokinin, PMN, polymorphonuclear cell). Reproduced with permission from Fig. 1. Physiology and pathophysiology of microvascular changes in acute pancreatitis. Cuthbertson CM and Christophi C. Disturbances of the microcirculation in acute pancreatitis. Br J Surg 2006; 93:518–530, John Wiley & Sons Ltd, Copyright © 2006