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. Author manuscript; available in PMC: 2017 Mar 1.
Published in final edited form as: Cell Signal. 2015 Jul 30;28(3):224–233. doi: 10.1016/j.cellsig.2015.07.021

Figure 2. Increased V1AR expression in human HF as well as large and small animal models of HF.

Figure 2

A) Realtime PCR reveals a significant increase in AVPR1A expression in failing (F) versus non-failing (NF) human and dog left ventricular samples, normalized to RPS18 and presented as RQ with RQmin and RQmax as error bars. Human heart tissue was obtained with institutional review board approval and patient consent as described in [80]. Failing dog heart samples were generated by pacing with IACUC approved as described in [148]. B) Saturation radioligand binding of 125I-AVP in membrane preparations of non-failing (NF) and failing (F) human heart and mouse left ventricular samples as previously described in [80 and 90]. Failing mouse heart samples were generated via transaortic constriction (TAC)-induced pressure overload with IACUC approval as described in [90]. *P<0.05, **P<0.01, ***P<0.001 unpaired t-test with Welch’s correction for unequal variance. Adapted from [80] with permission from Elsevier.