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. 2016 Jun 16;8:ecurrents.md.99d88e72634387639707601b237467d7. [Version 1] doi: 10.1371/currents.md.99d88e72634387639707601b237467d7

miR processing, canonical mode of action and miR-modulation scheme.

Fig1

MicroRNAs are transcribed as pri-miRs, processed to pre-miRs in the nucleus and finally processed to mature miRs in the cytosol, remaining associated with several proteins in a silencing complex (A). miR-mediated translational suppression requires interaction of microRNA with the 3’UTR of transcripts (B), and can potentially be inhibited by sequestration of miR (Sponge, C), masking of the binding site on 3’UTR (protector, D) or by interfering with miR maturation (analogue, E).