Table 1. Expression of GPCR genes encoding potential therapeutic targets for retinal degeneration in the Abca4^−/− Rdh8^−/− mouse model of bright light–induced retinopathy.

FPKM, normalized fragments per kilobase of exon per million mapped reads.

Gene*	Mouse retina (FPKM)	Human retina (FPKM)	Receptor	G protein signaling	Agonist	Antagonist
Drd4	241.78	139.49	Dopamine receptor D4	Gi	+
Gabbr1	40.24	35.38	γ-Aminobutyric acid B receptor 1	Gi	+
Drd2	23.1	26.33	Dopamine receptor D2	Gi	+
Adora1	18.26	13.55	Adenosine A1 receptor	Gi	+
Crhr1	6.49	12.76	Corticotropin-releasing hormone receptor 1	Gs		+
S1pr1	11.21	11.78	Sphingosine-1-phosphate receptor 1	Gi	+
Drd1a	9.49	8.45	Dopamine receptor D1a	Gs		+
Smo	6.35	5.91	Smoothened	Gi	+
Ednrb	1.94	5.77	Endothelin receptor type B	Gq		+
Grm1	3.52	4.97	Metabotropic glutamate receptor 1	Gq		+
Adrb1	20.18	3.84	β1-Adrenergic receptor	Gs		+
Adora2b	2.53	3.83	Adenosine A2B receptor	Gs and Gq		+
Hrh3	19.12	3.75	Histamine receptor H3	Gi	+
Grm4	4.93	3.1	Metabotropic glutamate receptor 4	Gi	+
Grm8	6.43	2.04	Metabotropic glutamate receptor 8	Gi	+
Grm7	3.95	1.16	Metabotropic glutamate receptor 7	Gi	+
Adra1a †	0.45	0.20	α1A-Adrenergic receptor	Gq
Adra1b †	1.60	1.12	α1B-Adrenergic receptor	Gq
Adra1d †	1.72	1.08	α1D-Adrenergic receptor	Gq
Adrb2	1.03	0.98	β2-Adrenergic receptor	Gs		+
Tacr1	2.06	0.95	Tachykinin receptor 1	Gq		+
Ptger1	14.88	0.94	Prostaglandin E receptor 1	Gq		+
S1pr2	1.13	0.63	Sphingosine-1-phosphate receptor 2	Gq, Gs, and Gi

^*Genes in bold, italicized font encode receptors targeted by the drugs displaying efficacy in this study.

^†Data from previous study (23).