Table 5. Effect of single and combination therapies on gene sets in pathways down-regulated in retinas from DMSO-treated, light-exposed mice.

Pathways were identified by GSEA. Only those pathways down-regulated in at least 50% of treatments are included.

Pathways	Experiment 1: Change in light-exposed retinas NES (P)*	BRM NES (P)†	MTP NES (P)†	TAM NES (P)†	DOX NES (P)†	Experiment 2: Change in light-exposed retinas NES (P)*	BRM + MTP + TAM NES (P)†	BRM + MTP + DOX NES (P)†
PHOTOTRANSDUCTION	−2.71 (0)	−2.42 (0)	−2.74 (0)	−2.79 (0)	−2.74 (0)	−2.70 (0)	−2.78 (0)	−2.31 (0)
OXIDATIVE	−1.78 (0)	−1.52	−1.40		−1.63	−1.33	−1.38
PHOSPHORYLATION		(0.010)	(0.019)		(0.0022)	(0.0362)	(0.0229)

^*Comparison of the transcriptomes from vehicle-treated and light-exposed retinas against those from the mice unexposed to bright light.

^†Comparison of the transcriptomes from vehicle-treated and light-exposed retinas against those from the mice treated by indicated drug(s).