TABLE 3.
Mean baseline-adjusted changes in office and ambulatory blood pressure variables at 6 months
| Renal denervation (n = 11) | Spironolactone (n = 13) | |||
| Variable | Change (Δ) at 6 months, mean (95% CI) | Change (Δ) at 6 months, mean (95% CI) | Mean baseline-adjusted difference (95% CI) between the two groups at 6 months (spironolactone versus RDN) | P |
| 24-h SBP (mmHg) | −5.7 (−14.8 to 3.4) | −23.6 (−31.9 to −15.3) | −17.9 (−30.9 to −4.9) | 0.01 |
| 24-h DBP (mmHg) | −3.7 (−8.2 to 0.9) | −10.2 (−14.4 to −6.1) | −6.6 (−12.9 to −0.3) | 0.04 |
| 24-h PP (mmHg) | −1.7 (−7.2 to 3.9) | −13.9 (−19.0 to −8.8) | −12.3 (−20.1 to −4.4) | 0.004 |
| 24-h HR (bpm) | 0.7 (−2.2 to 3.7) | 3.6 (0.9 to 6.2) | 2.8 (−1.4 to 7.0) | 0.2 |
| Day SBP (mmHg) | −5.7 (−14.8 to 3.4) | −23.6 (−31.9 to −15.3) | −17.9 (−30.8 to −4.9) | 0.009 |
| Day DBP (mmHg) | −3.0 (−7.4 to 1.5) | −9.8 (−13.9 to −5.8) | −6.9 (−13.0 to −0.7) | 0.03 |
| Day PP (mmHg) | −1.9 (−8.5 to 4.8) | −14.1 (−20.1 to −8.0) | −12.2 (−21.7 to −2.8) | 0.01 |
| Day HR (bpm) | 0.4 (−3.4 to 4.1) | 4.0 (0.6 to 7.4) | 3.6 (−1.6 to 8.9) | 0.2 |
| Night SBP (mmHg) | −7.7 (−18.8 to 3.4) | −22.3 (−32.4 to −12.2) | −14.6 (−30.2 to 0.9) | 0.06 |
| Night DBP (mmHg) | −5.5 (−11.2 to 0.3) | −10.9 (−16.1 to −5.9) | −5.4 (−13.4 to 2.6) | 0.2 |
| Night PP (mmHg) | −2.5 (−8.2 to 3.3) | −11.5 (−16.7 to −6.2) | −9.0 (−17.0 to −1.0) | 0.03 |
| Night HR (bpm) | 0.6 (−3.0 to 4.3) | 3.3 (0.0–6.7) | 2.7 (−2.5 to 7.9) | 0.3 |
| Office SBP (mmHg) | −17.5 (−29.7 to −5.1) | −29.4 (−40.7 to −18.1) | −12.1 (−29.1 to 5.1) | 0.2 |
| Office DBP (mmHg) | −7.5 (−15.5 to 0.5) | −12.7 (−20.0 to −5.5) | −5.3 (−16.3 to 5.8) | 0.3 |
| Office PP (mmHg) | −10.4 (−19.6 to −1.2) | −18.5 (−26.9 to −10.1) | −8.1 (−20.8 to 4.7) | 0.2 |
| Office HR (bpm) | 0.9 (−14.9 to 16.7) | 11.7 (−1.9 to 25.3) | 10.8 (−10.5 to 32.1) | 0.3 |
BP, blood pressure; bpm, beats per minute; CI, confidence interval; HR, heart rate.