TABLE 4.

Mean baseline-adjusted changes in renal function parameters at 6 months

	Renal denervation (n = 11)	Spironolactone (n = 13)
Variable	Change (Δ) at 6 months, mean (95% CI)	Change (Δ) at 6 months Mean (95% CI)	Mean baseline-adjusted difference (95% CI) between the two groups at 6 months (spironolactone versus RDN)	p
Serum creatinine (μmol/l)	5.9 (−2.3 to 14.1)	14.9 (7.4–22.4)	9.0 (−2.5 to 20.4)	0.1
eGFR (ml/min per 1.73 m2)	−3.0 (−9.8 to 3.9)	−13.7 (−20.0 to −7.4)	−10.7 (−20.1 to −1.4)	0.03
Serum potassium (mmol/l)	−0.13 (−0.36 to 0.11)	0.81 (0.60–1.03)	0.94 (0.62–1.25)	<0.001

CI, confidence intervals; eGFR, estimated glomerular filtration rate; RDN, renal denervation.