Table 2.
Altered expression levels of molecules involved in homologous recombination in cancers treated with radiation therapy. Expression of mRNA and/or protein was evaluated in human cancer specimens. Studies of cultured cells or in non-sporadic (familial or syndromic) cancer were excluded. Reproduced from Table 1, Kiyoshi Miyagawa, “Clinical relevance of the homologous recombination machinery in cancer therapy,” Cancer Sci 2008, page 190 (in Cancer Science, Volume 99, Issue 2, 2008, pages 187-194), permission pending (requested 1/27/10, may take 20 days).
| Gene/protein | Increased expression | Decreased expression |
|---|---|---|
| RAD51 | pancreatic cancer breast cancer non-small cell lung cancer head and neck cancer soft tissue sarcoma |
colorectal cancer breast cancer |
| RAD51C | breast cancer | |
| RAD52 | colorectal cancer | |
| BRCA1 | lung cancer ovarian cancer lung cancer |
breast cancer |
| BRCA2 | ovarian cancer | |
| MRE11 | breast cancer colorectal cancer |
|
| RAD50 | breast cancer | |
| NBS1 | head and neck cancer melanoma melanoma |
breast cancer colorectal cancer |
| BLM | chronic myelogenous leukemia lymphoma breast cancer breast cancer lung cancer renal cell cancer seminoma |
|
| WRN | chronic myelogenous leukemia colorectal cancer |
gastric cancer |
| FANCF | ovarian cancer cervical cancer |
|
| ERCC1 | non-small cell lung cancer ovarian cancer colorectal cancer |
non-small cell lung cancer gastric cancer colorectal cancer |