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. 2016 May 21;9:148–160. doi: 10.1016/j.ebiom.2016.05.025

Fig. 7.

Fig. 7

EBVness correlates with the presence of EBV DNA in breast cancer. (A–E) Fluorescent in situ hybridization of EBV DNA detected by probes against LMP1 or BXLF2 in breast cancer tissues or Burkitt's lymphoma. After in situ hybridization, the entire slide was scanned at high resolution suitable for virtual microscopy (A) Low power view of EBV DNA in situ hybridization of the entire tumor tissue section. (B) Anti-cytokeratin 5/6 stain of the same tissue section. (C) Medium power detail view (red box in A) and corresponding anti-cytokeratin 5/6 stain (D). (E) High power view of the green box in C. (F) Correlation of EBV DNA in situ hybridization with EBVness in 69 cases of breast cancer tissues. (G) EBV DNA in situ hybridization in Burkitt's lymphoma as a positive control. (H) High power view of the green image in G.