Fig. 3.

Effect of HPV16 E7 on expression of keratin genes at 2 weeks, 8 weeks and 20 weeks of age in transgenic mouse whole ear skin. (a) Volcano plot of differential expression of keratin genes between K14E7 and C57BL/6 mice. Significant genes above the threshold of log-ratio ≥± 2 are as labeled as colored rings while those that also attain statistical significance (adjusted p-value < 0.01) are labeled as solid orange (2 weeks), gold (8 weeks) or red (20 weeks) circles. (b) Differential expression of keratin genes categorized into subfamilies. Genes that are differentially expressed in a significant manner (adjusted p-value < 0.01) are plotted in orange (2 weeks), gold (8 weeks) or red (20 weeks) while genes that did not attain statistical significance are plotted in gray.