Fig. 2.
Mechanism of MG1 immune boost. The oncolytic virus MG1 expressing a tumour associated antigen transiently infects B cells in the splenic follicle. Antigens expressed on these cells are transferred to follicular dendritic cells that present antigen to TCM cells. The splenic follicles are immune privileged sites as TEFF cells can not enter. Therefore, follicular dendritic cells are protected from TEFF cell killing, a negative feedback loop (Bridle et al., 2016). This provides a mechanism for the large anti-tumour immune responses observed following treatment with MG1 expressing a tumour antigen (Pol et al., 2014).