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. Author manuscript; available in PMC: 2016 Oct 5.
Published in final edited form as: Leukemia. 2016 Apr 5;30(8):1682–1690. doi: 10.1038/leu.2016.70

Fig. 3. BMI1 inhibition suppresses growth of BV173 or SUP-B15 cells in NSG mice.

Fig. 3

(A, C) Kaplan-Meier plots show survival of NSG mice injected with 2×106 parental, scramble, or shBMI1 silenced (shBMI1 #1 and #2) BV173 (A) or SUP-B15 (C) cells. Mice injected with parental cells were left untreated while those injected with scramble, shBMI1 #1 and #2 BV173 cells or shBMI1 SUP-B15 cells were continuously treated with Doxy in the drinking water (2 g/L) starting three days post-cell injection. (B) Expression of BMI1 in CD10-cALLA+ cells sorted from the bone marrow of 3 leukemic NSG mice injected with shScr BV173 (ShScr) or with shBmi-1 BV173 cells (ShBmi-1). GRB2 expression was used as loading control.