Figure 1.

Characteristics of somatic mutations detected at primary and relapse APL. (a) Comparison of mutational load between primary and relapse APL. Boxplots depict median and range for numbers of nonsynonymous and synonymous variants identified per exome. Difference between average number of variants between two groups was estimated using two-tailed Student's t-test. (b) Clustering analysis using variant allele frequencies (VAFs) of all somatic variants (VAF ⩾0.08) observed at primary and relapse APL. DS2 and DS6 are shown as two representative cases, which harbor common or exclusive somatic mutations, respectively, at initial diagnosis and relapse.