Fig. 4. M-cell depletion in mice prevents mediastinal lymph node dissemination and prolongs survival during aerosol infection.
a–c, Balb/c mice (n=35–40/group in total) were aerosol infected with ~200 CFU Mtb and CFU in lung (a) or mediastinal LN (b) measured 18 days later. Results are pooled from 4 independent experiments conducted with 8–10 mice per treatment. c, Mice infected as above were monitored for survival (n=10/group). For CFU, statistical significance was determined by the Mann-Whitney U test. For survival, Kaplan-Meier analysis was performed.