Table 2.

Etravirine pharmacokinetic parameters.

Parameter	2nd Trimester n = 5	3rd Trimester n = 13	Postpartum n = 8	Geometric mean 3rd/Post Ratio	Historical Control
AUC0–12 (mcg*h/mL)	4.5 (3.4–10.7)	8.3 (2.7–31.0)	5.3 (2.1–16.4)	1.34	6.03 (Schöller-Gyüre et al., 2009)
C0 (mcg/mL)	0.26 (0.07–1.05)	0.60 (<0.005–2.64)	0.43 (<0.005–1.21)	2.03	0.28 (0.10–0.85) (Boffito et al., 2007)
Cmax (mcg/mL)	0.70 (0.44–1.05)	1.01 (0.26–3.47)*	0.63 (0.30–1.60)	1.34	0.44 (0.20–1.50) (Boffito et al., 2007)
Tmax (h)	2 (0–8)	4 (2–6)	4 (1–4)	1.10	4 (1–6) (Schöller-Gyüre et al., 2009)
C12 (mcg/mL)	0.36 (0.08–0.75)	0.48 (0.08–1.94)*	0.38 (0.07–1.14)	1.41	0.47 (Schöller-Gyüre et al., 2009)
Cmin (mcg/mL)	0.25 (0.07–0.75)	0.45 (<0.005–1.94)	0.38 (<0.005–1.14)	1.94	0.24 (0.09–0.73) (Boffito et al., 2007)
CL/F (L/h)	44 (19–59)	24 (6–74)*	38 (12–95)	0.75	†

AUC_0-12, area under the concentration vs. time curve from 0 to 12 h; C₀, pre-dose concentration; C_max, maximum concentration; T_max, time at which maximum concentration occurred; C₁₂, 12 h post-dose concentration; C_min, minimum observed concentration; T_min, time at which minimum concentration occurred; CL/F, oral clearance. Data are represented as median (range).

^*p < 0.05 for 3rd trimester vs. postpartum values using Wilcoxon signed-rank test. For other pharmacokinetic parameters in the 3rd trimester and postpartum, n = 13 and 8, respectively. Historical data AUC_0–12 mean was 4.2 mcg*h/mL among non-pregnant adults (Boffito et al., 2007) and 6.03 mcg*h/mL among non-pregnant women (Schöller-Gyüre et al., 2009).

^†Describes data which was absent in referenced study.