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Secondary prophylaxis after toxoplasmosis disease
| Intention | Intervention | SoR | QoE | Comments | Ref |
|---|---|---|---|---|---|
| To prevent relapse of CNS toxoplasmosis | Pyrimethamine (25 mg/day)a + sulfadiazine (orally, 30 mg/kg/d) | A | IIt | Minimum duration for 3 months, many cases longer | [204, 206] |
| Pyrimethamine (25 mg/d)a + clindamycin (intravenously, 1200 mg/d) | B | IIt | [255–257] | ||
| Atovaquone 750 mg qid | B | IIt | In patients intolerant to conventional toxoplasmic encephalitis therapies | [206] |
aShould be combined with folinic acid
