Fig. 5.

Physicochemical properties of size variants, as assessed by SE-HPLC (a) and rCE-SDS (b) for ABP 501 (red line), adalimumab (US) (black line), and adalimumab (EU) (blue line). Adalimumab (EU) European Union-authorized adalimumab, adalimumab (US) United States Food and Drug Administration-licensed adalimumab, AU absorbance units, HC heavy chain, HMW high molecular weight, LC light chain, LMW low molecular weight, mAU milli absorbance units, MMW medium molecular weight, NGHC non-glycosylated heavy chain, rCE-SDS reduced capillary electrophoresis-sodium dodecyl sulfate, SE-HPLC size exclusion-high-performance liquid chromatography