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. 2016 Aug 4;3(4):ENEURO.0112-15.2016. doi: 10.1523/ENEURO.0112-15.2016

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Copyright © 2016 Abburi et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

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Fig. 6. — Nicotine pretreatment occludes HFS-induced LTD in enkephalin-positive MSNs in the DLS. A, Representative EPSCs from putative D₂-containing MSNs from vehicle- and nicotine-pretreated rats during baseline and after HFS. B, Time course of the effects HFS on evoked EPSC amplitudes in vehicle- (open symbols) and nicotine- (filled symbols) pretreated groups. C, Summary data showing that HFS induces LTD of the excitatory inputs to DLS MSNs in vehicle-pretreated rats, but not in nicotine-pretreated rats (unpaired t test baseline vs HFS, *p < 0.05; vehicle, n = 9; nicotine, n = 7).